University of Birmingham > Talks@bham > Physics and Astronomy Colloquia > Haemodynamics and blood rheology - key factors in the recruitment of white blood cells and platelets to the wall of blood vesselsid dynamics of blood flow

Haemodynamics and blood rheology - key factors in the recruitment of white blood cells and platelets to the wall of blood vesselsid dynamics of blood flow

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If you have a question about this talk, please contact Prof Clive Speake.

Controlled recruitment of white blood cells and of platelets to the wall of blood vessels is essential to fight infection and prevent leakage of blood. In contrast, uncontrolled and unwanted recruitment underlies a range of common diseases. Efficiency of delivery of cells to the wall and of their attachment upon arrival are critical factors in initial deposition. These processes are strongly dependent on the local haemodynamics, the rheological behaviour of the blood (in which red cells occupy a much larger fraction than the white cells or platelets) and the microrheology of the protein-protein interactions which actually bind the cells to the surface. Added complexity comes from the fact that the properties of the adhesive surface (the endothelium) are influenced by the shear forces it experiences. The critical physical factors influencing cell delivery, adhesive interactions and the state of the vessel wall will be reviewed, with reference to some abnormal behaviours that underlie pathology, and to some of the outstanding holes in our understanding.

This talk is part of the Physics and Astronomy Colloquia series.

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