University of Birmingham > Talks@bham > Applied Topology Colloquium > Quantifying tumor heterogeneity with spatial omics

Quantifying tumor heterogeneity with spatial omics

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  • UserDr Marianna Rapsomaniki
  • ClockFriday 01 April 2022, 14:00-15:30
  • HouseY3 - Room B04.

If you have a question about this talk, please contact Jack Sykes.

Tumor heterogeneity has emerged as a fundamental property of most human cancers, with broad implications for diagnosis and treatment. Recently, single-cell spatial omics have revolutionized spatial tumor profiling, however computational resources that exploit the measurements to quantify tumor heterogeneity in a spatially-aware manner are largely missing. In this talk I will present ATHENA , a computational framework that facilitates the visualization, processing and analysis of tumor heterogeneity from spatial omics measurements. ATHENA employs graph representations of tumors and bundles together a large collection of established and novel heterogeneity scores that quantify different aspects of the complexity of tumor ecosystems. As spatial single-cell omics datasets become increasingly available, we hope that ATHENA will be a valuable resource for accurate tumor heterogeneity analyses.

This talk is part of the Applied Topology Colloquium series.

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