Adventures in Nano-land: Next-generation Tools for Single-Molecule Biophysics

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• Dr Lisa-Maria Needham, University of Wisconsin-Madison and University of Cambridge
• Wednesday 09 March 2022, 15:00-16:00
• https://bham-ac-uk.zoom.us/j/82696795200?pwd=NGRNVWVtMHhYVWExMkhHTnpjZHlOUT09.

If you have a question about this talk, please contact Josh Makepeace.

I2S/MSBC Seminar

Optical single-molecule techniques enable us to see the innate heterogeneities of complex systems that are masked by the ensemble average. This seminar will give you an overview of my adventures into the world of single-molecule biophysics, particularly on the development of new methods to facilitate the study nanoscale species in greater detail. Optical detection and spectroscopy of single biomolecules requires a signal generated by an emitter, this signal can be manipulated in two ways; 1) by modifying the properties of the emitter and 2) by controlling the environment into which the signal is emitted. I will begin with my PhD work on the design of new fluorescent probes and novel ways of augmenting existing probes for single-molecule tracking in live cells and to study of amyloid proteins. In this regime we modulate single-emitters to improve temporal and spatial information of biological systems. I will finish with a short summary of my current postdoctoral work in improving light-matter interactions inside optical microcavities, here I am working to control the surrounding emitter environment by temporally and spatially confining light within an optical resonator in the endeavour to generate new techniques for label-free single-molecule spectroscopy of biomolecules.

This talk is part of the School of Chemistry Seminars series.

This talk is included in these lists:

• https://bham-ac-uk.zoom.us/j/82696795200?pwd=NGRNVWVtMHhYVWExMkhHTnpjZHlOUT09
• School of Chemistry Seminars

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