University of Birmingham > Talks@bham > CCB seminars > Understanding the interplay of enhancers, chromatin priming elements and signals regulating dynamic gene expression in development

Understanding the interplay of enhancers, chromatin priming elements and signals regulating dynamic gene expression in development

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The developmental control of gene expression is a highly dynamic process that ensures that genes are expressed at the correct time, in the correct cell type and at the correct level. This process is regulated via a complex interplay of transcription factors (TF) and molecules that change chromatin structure. Using the amount of sequencing-based data available for the different stages of haematopoietic specification of murine ES cell, our project goal is to predict enhancer/priming element activity and thus understand the temporal regulation of gene expression. In this seminar, I will present, 1) the biological problem; 2) a Machine Learning technique called iterative Random Forests (iRF) that through training a classifier, it discovers important (nonlinear) interactions between features (TF binding patterns, chromatin marks and chromatin state) that define enhancer activity for subsets of genomic elements; 3) a bias in the data due to the biological nature of the problem; 4) and possible new approach to deal with this bias.

This talk is part of the CCB seminars series.

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