Topology and Dynamics of Intracellular Networks for Cellular Decision Making

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• Fabian Spill, Birmingham
• Monday 30 November 2020, 14:00-15:00
• https://bham-ac-uk.zoom.us/j/84366477677.

If you have a question about this talk, please contact Johannes Carmesin.

Cells are the central units of life that perform various functions; for example, they can grow, divide or move. They do this in response to signals from the environment that they sense though networks of intracellular reacting molecules. In simple terms, these networks have some inputs (e.g. chemical signals telling a cell to divide) and outputs (e.g. some molecules that make the cell divide). Fundamentally, two topological features characterise the response of cells to signals: the topology of the network of the chemicals and their reactions. And the topology of the phase space characterising the dynamic changes of the concentrations of molecules. The latter determines, for example, if the chemicals will evolve towards some fixed points, or whether the dynamics is characterised by oscillating solutions. I will give an overview to this field and discuss some of the challenges towards the goal to uncover accurate mathematical representations of the intracellular reaction networks.

This talk is part of the Study group in Graph Theory, Topology and Algorithms series.

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• https://bham-ac-uk.zoom.us/j/84366477677

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