A computational model of vascular regression

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• Jessica Crawshaw, University of Melbourne
• Tuesday 10 December 2019, 13:00-14:00
• Nuffield G17.

If you have a question about this talk, please contact Fabian Spill.

Note date and place outside of usual slot.

Vascular regression refers to the pruning of superfluous vessels from a capillary network. Whilst it is accepted that the local haemodynamic environment has some role in regression in the developing retinal vasculature, it is difficult to experimentally distinguish the relative contribution of the haemodynamic forces from those of the cellular signalling pathways. As such, the development of computational models to analyse the relationship between blood flow and vascular regression are invaluable.

We are developing computational models to examine the relationship between endothelial cell migration and haemodynamic forces during vascular regression in the developing retinal network of neonatal mice (postnatal day 5). A cell-based model is used to describe the endothelial cell population over a hyperelastic capillary network taken from confocal images of the retinal vasculature. Endothelial cell migration is regulated by the local haemodynamic environment, which is modelled using a computational fluid dynamics tool. The subsequence vessel collapse and evolution of the network will be simulated over long time periods.

These computational models will enable us to gain insight into the dynamic relationship between the endothelial cells, the capillary wall and the local haemodynamic environment, as well as provide a framework to computationally analyse and interrogate the relationship between mechanical forces and vascular regression.

This talk is part of the Applied Mathematics Seminar Series series.

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• Applied Mathematics Seminar Series
• Nuffield G17
• School of Mathematics events

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