University of Birmingham > Talks@bham > Applied Mathematics Seminar Series > Structure, function and growth in asthmatic airways: towards integration of mechanistic models and experimental data

Structure, function and growth in asthmatic airways: towards integration of mechanistic models and experimental data

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  • UserBindi Brook, University of Nottingham
  • ClockThursday 12 December 2019, 13:00-14:00
  • HouseNuffield G13.

If you have a question about this talk, please contact Fabian Spill.

Asthma is a chronic lung disease affecting approximately 5.4 million people in the UK. Severe asthmatics suffer frequent exacerbations requiring hospitalisation, and furthermore, there are 3 asthma-related deaths a day in the UK. There is no real cure and its pathogenesis is not clearly understood. The disease is characterised by inflammation, airway hyper responsiveness (excessive contraction of the airways) and remodelling (irreversible structural changes in the airway). While each of these hallmarks have been studied extensively, it is not clear whether they develop independently or if one is responsible for another. In this talk I will describe the mechanistic models we have developed to understand these characteristics and how they may be linked. In particular I will focus on (i) airway contraction models based on continuum descriptions of soft tissue mechanics coupled to biophysical models of protein interactions that generate contractile force in airway smooth muscle cells lining the airway and (ii) the consequences of mechanical stresses generated in the airway on remodelling, via feedback into airway smooth muscle cell functions such as proliferation and phenotype switching. I will describe how we intend to explore homoeostasis in the normal airway using these models together with extensive structure, function and remodelling data obtained from tailored mouse model experiments.

This talk is part of the Applied Mathematics Seminar Series series.

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