University of Birmingham > Talks@bham > Applied Mathematics Seminar Series > Centrosome positioning and asymmetric division in polarized cells: Torque generation in the early C. elegans embryo

Centrosome positioning and asymmetric division in polarized cells: Torque generation in the early C. elegans embryo

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  • UserAdriana Dawes, Ohio State University
  • ClockThursday 03 October 2019, 13:00-14:00
  • HouseNuffield G13.

If you have a question about this talk, please contact Fabian Spill.

Lunch with the speaker at staff house 12, tea after the talk

Asymmetric cell division, where daughter cells inherit unequal amounts of specific factors, is critical for development and cell fate specification. Polarized cells, characterized by factors segregated to spatially distinct regions in the cell, often divide asymmetrically by positioning the centrosomes along the polarity axis. Using an individual-based stochastic model of microtubule dynamics nucleated at the centrosomes, and experiments in the early C. elegans embryo, we explore potential sources of cortical force generation and demonstrate the role of both cortical and centrosomal asymmetries for recapitulating the in vivo dynamics and proper positioning of the centrosomes prior to first division.

This talk is part of the Applied Mathematics Seminar Series series.

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