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How to build a biological nanomachine

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  • UserDr Andela Šarić, Department of Physics and Astronomy, Institute for the Physics of Living Systems, University College London
  • ClockTuesday 29 October 2019, 14:00-15:00
  • HouseBiosciences 301.

If you have a question about this talk, please contact Dr Dwaipayan Chakrabarti.

I2S Seminar hosted by Dr Dwaipayan Chakrabarti

The molecular machinery of life is largely created via self-organisation of individual molecules into functional assemblies. Such processes are multi-scale in nature and constantly driven far from thermodynamic equilibrium. Our group develops minimal coarse-grained computer models to help understand how self-organisation of a large number of macromolecules results in a functional nanomachine.

Here I will discuss the physical mechanisms behind two key biological nanomachines that operate via protein assembly – active elastic ESCRTIII filaments that remodel cell membranes and split cells in two, and mechanosensitive bacterial channels that convert mechanical signals into chemical. I will discuss the model development, the simulation results, and the mapping of the simulation data to in vivo experiments. Beyond their biological context, our findings can also guide the design of artificial structures that are able to perform work at the nanoscale.

This talk is part of the School of Chemistry Seminars series.

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