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Applications of Parahydrogen-Hyperpolarised NMR at High and Low Magnetic Field

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  • UserDr Meghan Halse, Department of Chemistry, University of York
  • ClockTuesday 30 April 2019, 14:00-15:00
  • HouseMech Eng - G34.

If you have a question about this talk, please contact Dr Dwaipayan Chakrabarti.

I2S Seminar hosted by Dr Melanie Britton

Nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) are powerful analytical techniques with applications in fields ranging from synthetic chemistry to clinical diagnosis. Despite the power of these techniques, many potential applications of magnetic resonance are limited by its inherent insensitivity. A range of hyperpolarisation methods have been introduced that boost the sensitivity of NMR and MRI by increasing the population imbalance between nuclear energy levels from the ppm levels that exist at thermal equilibrium up to as much as 10’s of percent. In this presentation I will focus on parahydrogen-induced polarisation (PHIP), which uses the singlet nuclear spin isomer of H2, parahydrogen (p-H2), as the source of polarisation. Parahydrogen is an attractive polarisation source as it is relatively cheap and easy to produce, can be stored for weeks to months, and can provide orders of magnitude signal enhancements using relatively simple and inexpensive instrumentation. In this talk I will discuss a range of applications of parahydrogen-enhanced NMR with a particular focus on reaction monitoring using in situ photochemistry and the integration of p-H2 hyperpolarisation with low-field, portable NMR devices from a 1 T benchtop instrument to an Earth’s field NMR spectrometer.

This talk is part of the School of Chemistry Seminars series.

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