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School Seminar: The importance of mechanistic chemistry in toxicology

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  • UserProf. Andrew Smith, MRC Toxicology Unit, University of Leicester
  • ClockTuesday 20 February 2018, 14:00-15:00
  • HouseHaworth 203.

If you have a question about this talk, please contact Dr Dwaipayan Chakrabarti.

School Seminar and RSC Toxicology Award Lecture hosted by Dr John Fossey

Toxicology has been at the forefront of using many revolutionary biological approaches in the safety assessments of drugs, pesticides and other chemicals including environmental agents. It is important however, not to lose sight of trying to understand mechanistically what is happening at a molecular level. Not only is appreciation of the relevance for human and animal health enhanced but it may stimulate new rational approaches for drug development and chemical use. A number of fundamental toxicological questions that could be explored more mechanistically will be suggested in both old and new fields. In addition, mechanistic studies will be described of the hepatic toxicity and carcinogenicity of some polyhalogenated chemicals that disrupt haem metabolism and closely related to the human porphyria usually seen in alcoholic or oestrogen-treated patients. Findings also illustrate inconsistencies in some current toxicological concepts.

This talk is part of the School of Chemistry Seminars series.

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