How do antibiotics work? Linking antibiotic inhibition to bacterial physiology using theoretical models and experiments.

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• Rosalind Allen, University of Edinburgh
• Thursday 07 December 2017, 12:00-13:00
• Nuffield G17.

If you have a question about this talk, please contact Meurig Gallagher.

Many experiments on bacterial action and the evolution of resistance are done in standardised lab conditions, yet bacteria in infections experience complex growth conditions, which can vary in time and space. Exposure to nutrients can also vary between different infections. We have investigated how the richness of the nutrient medium affects the efficacy of action of ribosome-targeting antibiotics. We find apparently conflicting results: some ribosome targeting antibiotics work better on rich media while others work better on poor media. These results can be explained by a simple mathematical model, which also makes predictions for the dynamical effects of antibiotics which are potentially clinically relevant but have yet to be tested.

This talk is part of the Applied Mathematics Seminar Series series.

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• Applied Mathematics Seminar Series
• Nuffield G17
• School of Mathematics events

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