University of Birmingham > Talks@bham > Medical Imaging Research Seminars > Multispectral Imaging for in vivo assessment of murine arthritis models

Multispectral Imaging for in vivo assessment of murine arthritis models

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If you have a question about this talk, please contact Matthaios Doulgerakis.

Murine models of Rheumatoid Arthritis are currently assessed by manual inspection and scoring based on observation of mouse appearance and behaviour. This method of symptom assessment is highly subjective and can vary between different researchers. We are aiming to develop an imaging system to be used in adjunct to this process to aid in continuous mouse assessment in longitudinal experiments. A Multispectral Imaging system has been developed incorporating reflection and transmission capability for the purpose of imaging mouse hind paws. Initial results from imaging of TNFdARE+/- mice and normal control littermates indicate differences between healthy and affected mice consistent with a decrease in oxygenation. Blind scoring of the mice by manual inspection identified 4 of 8 mice to be presenting symptoms. Multispectral imaging and spectral assessment of specific paw regions correctly identified 5 affected mice, matching the genotyping. These results suggest Multispectral Imaging has potential to be a more accurate form of mouse arthritis assessment. Further work will involve assessing different models of arthritis and identifying symptoms as early as possible.

This talk is part of the Medical Imaging Research Seminars series.

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