RSC 2016 Peter Day Award Lecture: Peptides Conjugates: From Self-assembly Towards Applications in Biomedicine

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• Prof. Ian Hamley, Department of Chemistry, University of Reading
• Tuesday 17 January 2017, 14:00-15:00
• Sport Ex LT1.

If you have a question about this talk, please contact Dr Dwaipayan Chakrabarti.

RSC 2016 Peter Day Award Lecture and School seminar hosted by Dr Dwaipayan Chakrabarti

Self-assembling peptides and their conjugates offer exceptional potential in nanomedicine. I will present some of our recent work on nanoscale assembled peptides and their conjugates, focussing on lipopeptides. Examples from our recent work on self-assembling lipopeptides (peptides attached N- terminally to palmitoyl, hexadecyl, lipid chains) will be outlined. Our focus is to investigate potential relationships between self-assembly and bioactivity, in particular in the fields of regenerative medicine [1-5], antimicrobial systems [6,7], and immune therapies [8,9]. I will also present selected results from our work on self-assembling polymer-peptide conjugates incorporating poly(ethylene glycol), PEG , including a thermoresponsive and biocompatible PEG /peptide hydrogel [10].

References

1. Jones, R. R.; Castelletto, V.; Connon, C. J.; Hamley , I. W., Collagen Stimulating Effect of Peptide Amphiphile C16 −Kttks on Human Fibroblasts. Molecular Pharmaceutics 2013, 10, 1063-1069.

2. Gouveia, R. M.; Castelletto, V.; Alcock, S. G.; Hamley , I. W.; Connon, C. J., Bioactive Films Produced from Self-Assembling Peptide Amphiphiles as Versatile Substrates for Tuning Cell Adhesion and Tissue Architecture in Serum-Free Conditions. J. Mater. Chem. B 2013 , 1, 6157-6169.

3. Castelletto, V.; Gouveia, R. J.; Connon, C. J.; Hamley, I. W.; Seitsonen, J.; Ruokolainen, J.; Longo, E.; Siligardi, G., Influence of Elastase on Alanine-Rich Peptide Hydrogels. Biomater. Sci. 2014, 2, 867-874.

4. Gouveia, R. M.; Castelletto, V.; Connon, C. J.; Hamley, I. W., New Self-Assembling Multi-Functional Templates for the Bio-Fabrication and Controlled Self-Release of Live Human Tissues. Tissue Engineering Part A 2015 , 21, 1772-1784.

5. Hamley, I. W.; Dehsorkhi, A.; Castelletto, V.; Walter, M. N. M.; Connon, C. J.; Reza, M.; Ruokolainen, J., Self-Assembly and Collagen Stimulating Activity of a Peptide Amphiphile Incorporating a Peptide Sequence from Lumican. Langmuir 2015, 31, 4490-4495.

6. Dehsorkhi, A.; Castelletto, V.; Hamley, I. W.; Seitsonen, J.; Ruokolainen, J., Interaction between a Cationic Surfactant-Like Peptide and Lipid Vesicles and Its Relationship to Antimicrobial Activity. Langmuir 2013, 29, 14246-14253.

7. Hamley , I. W.; Dehsorkhi, A.; Castelletto, V., Self-Assembled Arginine-Coated Peptide Nanosheets in Water. Chem. Comm. 2013, 49, 1850-1852.

8. Hamley, I. W.; Kirkham, S.; Dehsorkhi, A.; Castelletto, V.; Reza, M.; Ruokolainen, J., Toll-Like Receptor Agonist Lipopeptides Self-Assemble into Distinct Nanostructures. Chem. Comm. 2014, 50, 15948-15951.

9. Castelletto, V.; Kirkham, S.; Hamley, I. W.; Kowalczyk, R.; Rabe, M.; Reza, M.; Ruokolainen, J., Self-Assembly of the Toll-Like Receptor Agonist Macrophage-Activating Lipopeptide Malp-2 and of Its Constituent Peptide. Biomacromolecules 2016, 17, 631-640.

10. Hamley, I. W.; Cheng, G.; Castelletto, V., Self-Assembly of Telechelic Peg End-Capped with Hydrophobic Dipeptides. Macromolecular Bioscience 2011, 11, 1068-1078.

This talk is part of the School of Chemistry Seminars series.

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• School of Chemistry Seminars
• Sport Ex LT1

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