BSN Seminar: Metal-based Chemical Entities: Opportunities in Chemical Biology and to Achieve Targeted Therapeutic Agents

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• Prof. Angela Casini, School of Chemistry, Cardiff University
• Tuesday 15 November 2016, 14:00-15:00
• MechEng - G34.

If you have a question about this talk, please contact Dr Dwaipayan Chakrabarti.

BSN Seminar hosted by Prof. Zoe Pikramenou

My research interests concern mainly the study of the modes of action of metal compounds as anticancer agents and the development of novel metal-based chemical entities with possible biological applications. Besides synthetic inorganic chemistry and structural characterization of new metal complexes (mainly gold coordination and organometallic compounds), we strongly focus on an intensive biological evaluation of the new compounds as possible therapeutic agents, and on the investigation of their mechanisms of pharmacological activity and toxicity. To this aim, we have achieved target identification for different families of gold(I) and gold(III) complexes, including the membrane water channels aquaporins,[1] as well as proteins’ zinc finger domains.[2] Furthermore, applications for novel metal-based compounds and supramolecular self-assembled coordination complexes have been explored in various domains of chemical biology, bio-analytical chemistry and drug delivery. Here, I present recent results from our group representative of this interdisciplinary approach, which takes advantage of biophysical and analytical techniques coupled to pharmacological methods.

This talk is part of the School of Chemistry Seminars series.

This talk is included in these lists:

• MechEng - G34
• School of Chemistry Seminars

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