Uncertainty in cardiac electrophysiology models - identifiability, parameterisation and model selection

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• Dr Gary Mirams, University of Oxford
• Monday 18 January 2016, 15:00-16:00
• Lecture Theatre 4, Strathcona Building.

If you have a question about this talk, please contact David Smith.

Mathematical cardiac electrophysiology models have been used for over 50 years to understand the mechanisms by which the heart beat is generated and adapts to changes in physiological demands. The success of the field has led to an explosion of different models of ion currents and different collections of them to simulate electrophysiology of cardiac cells. For just one particular potassium current – the IKr current carried through the hERG channel – we have counted over 30 mathematical ODE models (or parameterisations of around 10 structures). We discuss how we went back to the beginning and attempted to design experiments to select the correct model structure, as well as to identify parameters in the models as uniquely as practical. We will show how this is allowing us to quantify variability in ionic current properties between cells for the first time.

This talk is part of the Applied Mathematics Seminar Series series.

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• Applied Mathematics Seminar Series
• Lecture Theatre 4, Strathcona Building
• School of Mathematics Events

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