High-Resolution Differential Ion Mobility Separations with Mass Spectrometry and Selected Bioanalytical Applications

Add to your list(s) Download to your calendar using vCal

• Alexandre Shvartsburg, Wichita State University
• Friday 08 January 2016, 13:00-14:00
• WG4, Biosciences.

If you have a question about this talk, please contact Dr Andrew Creese.

Most biological and environmental analyses require separations prior to mass spectrometry, and the condensed-phase approaches are now increasingly replaced or supplemented by rapid ion mobility spectrometry (IMS) in gases. Early IMS methods at moderate electric fields were linear (based on the absolute mobility), but the mobility depends on the field intensity. That enables field asymmetric waveform IMS (FAIMS) that sorts ions by the difference between mobilities at high and low fields. Major gains of FAIMS resolving power now allow previously unthinkable applications. We will discuss the fundamentals of high-resolution FAIMS , latest instrumental developments involving high-definition waveform generators, gas buffers rich in helium and hydrogen, and effective coupling to MS and ETD using ion funnels, and applications to proteomics (especially the localization of post-translational modifications), structural biology, metabolomics, and isotopic analyses.

This talk is part of the Type the title of a new list here series.

This talk is included in these lists:

• Type the title of a new list here
• WG4, Biosciences

Note that ex-directory lists are not shown.